Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
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چکیده
منابع مشابه
α-Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity
A key feature of Parkinson disease is the aggregation of α-synuclein and its intracellular deposition in fibrillar form. Increasing evidence suggests that the pathogenicity of α-synuclein is correlated with the activity of oligomers formed in the early stages of its aggregation process. Oligomers toxicity seems to be associated with both their ability to bind and affect the integrity of lipid m...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aan6160